Caffeine Cleanse Aid: Rutaecarpine

caffeine cleanse for better sleep

A caffeine cleanse or the desire to detoxify the body of caffeine is becoming increasingly popular as more awareness of caffeine’s addictive nature arises.

A natural chemical called Rutaecarpine could help.

There are several products on the market that contain Rutaecarpine and there is strong evidence supporting its ability to cleanse caffeine from the body much quicker.

How Rutaecarpine Helps

Most of these supplements contain 100mg of rutaecarpine extracted from the herb known as Evodea, which is rich in the chemical.

Recently a study published in the Archives of Pharmacal Research looked at rutaecarpine’s effect on caffeine metabolism in mice.

The team of researchers concluded the following:

These results clearly suggest that rutaecarpine increases the metabolism of caffeine, theophylline, theobromine, and paraxanthine by inducing CYP1A2 and CYP2E1 in rats.

Since mice and humans metabolize caffeine very similarly, the effects of rutaecarpine in regards to human caffeine metabolism are likely the same. Src.

WebMD notes Evodia’s interaction with caffeine and states that it may reduce caffeine’s effectiveness.

Therefore, the goal of rutaecarpine is to speed up the rate at which caffeine is broken down and removed from the body.

It is believed to assist in cleansing caffeine from the body, which eliminates the side-effects of caffeine much quicker including sleeplessness.

One such rutaecarpine product available is called De-Caffeinate and here’s how it’s used.

De-Caffeinate with rutaecarpine

Click here to learn more or to order De-Caffeinate. 

Benefits of Rutaecarpine

  • Useful for a faster caffeine cleanse.
  • Promotes better sleep for those who consume caffeine late in the day.
  • Useful for those who occasionally have too much caffeine i.e. students, drivers, and others in high demand professions.
  • Useful for those who want to reduce their daily caffeine amounts.
  • Useful for those extremely sensitive to caffeine.

Any Downsides?

  • Rutaecarpine will not lessen withdrawal symptoms, but only allows for faster caffeine detox.
  • Taking the herb does not allow people to consume as much caffeine as they want without dangerous consequences.
  • Some people may have allergic reactions to Evodia.
  • Evodia may inhibit blood from clotting.
  • Evodia isn’t suitable for pregnant or nursing mothers.

While the human body is able to naturally breakdown and cleanse caffeine from the body, there may be times when a more speedy detox is required. Rutaecarpine could help in those situations.

Here’s what one user of De-Caffeinate reported.

Great product if you like coffee but it keeps you awake at night. This really works for me. I can do my caffeine without the worry of it keeping me up.- Professor Osmond


  • De-Caffeinate has a 30 day 100% money back guarantee.
  • It’s manufactured in the USA and developed by pharmacists.

Learn more or order De-Caffeinate here.

Reasons to Cleanse Caffeine

While most experts, including us, agree that caffeine in moderation seems ok and can even be healthy in the form of coffee or tea, some people lack the ability to moderate.

One cup turns into two, then three, and so on until a person’s health and sleep begin to become compromised by the excessive caffeine amounts.

For these people a caffeine cleanse can be a smart way to get things back under control or to get the sleep you need.

  1. Daily consumption is well beyond what is considered safe.
  2. Caffeine is causing sleep problems and insomnia.
  3. Coffee or energy drink habit is straining finances.
  4. A medical condition requires the quitting of caffeine.
  5. The desire to no longer be addicted to caffeine.
  6. Caffeine tolerance is too high and caffeine no longer has the desired effect.

In any event, a caffeine cleanse isn’t easy due to the addictive nature of caffeine. Moderate to severe withdrawal symptoms can be experienced and the detox process takes time.

Have you tried a caffeine cleanse using rutaecarpine? Did it work for you? 

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  • Johnny Boy

    I am hyper sensitive to Caffeine and noticed I had problems falling asleep at night after having a lightly caffeinated product before noon that day. I have always been a moderate person and I don’t tend to have an addicitive personality with anything, including caffeine. So I googled “anti-caffeine”, found this product, and figured why not? I now take one a couple hours before bed (only on days I had caffeine) and I can tell that I am naturally tired and fall asleep with much more ease. Great product, worked for me, that’s why I am taking the time to post this one…

  • Jane

    Is this safe for people who take stimulant medication for ADHD?

  • Ted
  • Jane

    Hmm I dont see Concerta on there. Hopefully its safe then.

  • Shayne Warren

    Well, I was a serious coffee drinker, 20 plus mugs of strong black coffee with 1 and half spoon sugar, and also 3 to 5 mugs of cuppachino with full cream milk and sugar. Today I am on day 32 of having gone cold turkey on the coffee, and by default sugar and milk. Been 4 weeks of pure hell, but now coming out of it, but that only means the withdrawals are now becoming less severe and actually had 3 or four night sleep for the first time since stopping coffee. Seems that I am going to be on that 2 month mark before my system resets. Going to try get hold of that herb you mention in your article, “Rutaecarpine –
    There is a new product called RUTAcleanse” Hopefully this will get me there quicker.

    My recommendation to those who are as heavy a coffee drinker as I was, is to wean yourself off coffee over a few weeks, DON’T do it cold turkey, it is hell. Do it slow but sure, it will be far more pleasant.

  • Marilyn

    Thanks for ur info. I drink coffee with cream and 2-3 spoons of sugar all day long. I was worried about withdtawl . I’m gonna try to wean myself for a few weeks first. What did u mean by hell. Is it painful. I’m scared

  • Corinne

    Hi Marilyn,
    To answer your question, is caffeine withdrawal painful? YES!!! Very painful!

    You will get these horrible migraines for exactly one month, i know I gave it up for Lent 2002 and never went back, although I did start with decaf, busy recently.

  • James

    Exactly how long do the headaches last? I am on day 22 and have had bad headaches all day, every day. Is this normal for withdrawal?

  • Moa

    I really like coffee, but I´m a hyper sensitive person to caffeine and getting bad affects as bloated stomach and aches, tense muscles, getting jittery and if I´m drinking “to much” which is only a normal size cup I can´t even handle the bad effect as they´re getting worse the more I drink. I mentioned that you can take this product two hours after a mug and then it maybe will be easier to sleep… but i wonder… because I never drink coffee late, and is disturbed by bad affects as I´m writing above… Is it possible to take this product before I drink some coffee so the effects doesn´t will be as bad as they are?
    Have a wonderful day!

  • Ted

    I’m not sure Moa, another hypersensitive person in the comments below tried it and it didn’t work so well. It seems like it’s best for those with normal caffeine sensitivity.

  • Moa Rönnbäck

    Okey, I understand! Thank you for your answer!

  • Cyrus T. Wolfwood

    Decaf still has caffeine in it….

  • Moriah

    I have Atrial Fib and aortic anyeurysm will this be safe for me to take? I recently got diagnosed with Silent Reflux, which is causing other bad effects..coughing, hoarsness etc. probably brought on by drinking coffee.

  • Ted

    You would have to ask your doctor this question.

  • that1dudeFromOC

    Does this help with other stimulants that are in preworkouts or pills like DMAA, yohimbee, or sypherine?

  • Ted

    Not sure if it has the same effect on the metabolism of other stimulants. I think the research only looked at its effect on caffeine.

Last Modified: June 13, 2017


  • Noh, K., Seo, Y. M., Lee, S. K., Bista, S. R., Kang, M. J., Jahng, Y., ... & Jeong, T. C. (2011). Effects of rutaecarpine on the metabolism and urinary excretion of caffeine in rats. Archives of pharmacal research, 34(1), 119-125. Study link
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